Combo Weight Loss Pill Fights Cravings and Appetite
An experimental obesity drug that combines the antidepressant bupropion and the addiction drug naltrexone reduces body weight by 5% or more after one year when combined with healthy diet and regular exercise, according to a new report published online in The Lancet.
If approved, the new drug may be the right choice for dieters who get waylaid by their food cravings because it taps into the brain’s craving and reward system in addition to curbing appetite. An FDA advisory panel is slated to review the drug, called Contrave, on Dec. 7. Manufacturer Orexigen Therapeutics, Inc. funded the new study.
In the 56-week study, participants received a high dose of the combination pill, a low dose, or a placebo twice a day. They were also advised to eat a low-calorie diet and engage in regular exercise. Those who took the higher dose of the new pill lost 6.1% of their body weight, while those who received the lower dose shed 5% of their body weight. By contrast, those people in the placebo group lost 1.3% of their body weight.
Fully 34% of people who took the high dose of the drug lost at least 10% of their body weight, compared with 11% who received the place
Ephedrine is one of the most effective and controversial substances used for weight loss. It is a potent fat loss agent and CNS stimulant (especially when combined with caffeine) and also effective in the treatment of asthma. However, there are also many reports of adverse events that are possibly associated with ephedrine use that have prompted many people to call for further regulation of the compound.
Listen closely because this article is going to reveal some little-known, almost secret facts about thyroid hormone, a piece of the fat-burning puzzle so overlooked that even many pro bodybuilders have trouble putting it in place at showtime. In fact, coming in “soft” is the number-one fear of every bodybuilder who’s ever carried armor-plated muscle onstage. Being called smooth is like someone talkin’ trash about your mom—you just don’t want to hear it. Thanks to ground-breaking research on a new thyroid-hormone-stimulating compound called T-3, however, the fear of being smooth will vanish. That’s because T-3 takes the fat-burning process to a level well beyond standard thermogenics.
Lets face it almost everyone has some spots of fat he or she wants to get rid off. This is called spot-reduction. I wrote about it here 
I have previously stated that I believe transdermal prohormones to be the most effective supplements ever to hit the market. That statement must now be amended. Transdermal prohormones are indeed the most effective MUSCLE BUILDING supplements ever to hit the market. But, topical fat loss products have the potential to be an even bigger overall breakthrough in the never ending quest to improve body composition.
A drug to make you thin! Drug marketers go glassy-eyed when they calculate the potential. At least 44 million Americans are obese -- as many as 60 million by some estimates. And for reasons that go well beyond the associated health problems, virtually everyone who is fat is desperate not to be. In a 1991 University of Florida survey of 47 formerly obese adults -- who had each lost 100 pounds or more through gastric bypass surgery -- the majority said they would rather be deaf or blind than be fat again. In a more recent study, children who were shown pictures of other children with various disabilities -- with crutches, in a wheelchair, with an amputated hand, and overweight -- picked the pudgy child as the most unlikable in the group. In a culture that so vilifies fat, it's difficult to imagine that an effective cure for the obese wouldn't quickly find its way to the merely overweight -- another 67 million customers.
More then 70% of what we eat is burned by our muscles, even in rest. So even when you are not develop any activity our muscles burn calories (Energy Expenditure at Rest). Only a small part of our caloric intake is used as energy to move or exercise. The more muscles you have the more calories you burn while resting. 
People not trained in the medical professions usually have the impression that, with thousands of medications stocked at a well-sorted pharmacy, we have the power to interfere with human physiology in thousands of ways, each specific to a certain medication.