Gene Therapy Can Improve Muscle Mass and Strength in Monkeys

A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders.

Severe weakness of the quadriceps is a defining feature of several neuromuscular disorders. Researchers at Nationwide Children’s Hospital have shown that a gene delivery strategy that produces follistatin – a naturally occurring protein that inhibits myostatin, a growth factor expressed specifically in skeletal muscle – directly to the quadriceps of non-human primates results in long-term gene expression with muscle enhancing effects, including larger muscles with greater strength.

 

How an experienced bodybuilder contaminated his own vials

For our book UNDERGROUND ANABOLICS we wanted a sample from a new UG line from the UK, ProChem Laboratories. I was able to get a vial from a bodybuilder that he had used twice. I thought 6 ml would be sufficient I sent the used ampoule with the rest of the samples to the laboratory for analysis. The lab ran all tests and the used vial showed an estimated colony forming unit (CFU) from 60.000. Since it was the only used vial I tried my best to find a new vial and I was able to buy a few in the UK, via a board-member. We sent this new vial in for a CFU test and this sample was not contaminated (see reports).

 

Why do I write down this story? I want you to realize that even an experienced bodybuilder (now competing the masters class) did contaminate one of his vials. Thus be careful, keep your vial in a dark, cool place. When you want to use them clean the stopper with alcohol, wait some time to allow sterilization. Use a new needle to fill the syringe, when the syringe is filled, take a new needle for the actual injection.

 

 Anabolic Update

  by William Llewelyn

New Designer Steroid    Muscular Development June 2007

 

 This month I thought it would be interesting to introduce readers to a new, underground steroid circulating on the black market. It’s called dimethylnandrolone (DMN) and as its name suggest, it’s a cousin to the popular drug Deca Durabolin (nandrolone decanoate), so highly favoured by athletes for its strong anabolic and mildly androgenic properties. Dimethylnandrolone or DMN for short, is an interesting analogue of nandrolone, displaying high relative potency and favourable estrogenic and androgenic characteristics. Although its emergence on the underground is fairly recent, it’s quickly gaining attention and favourable reviews. With this in mind, I figured a thorough examination was warranted. So, without further fanfare let’s find out what this new “designer” steroid is all about.

MT-DMN is also covered here:    //www.ergo-log.com/mtdmn.html

Bikinis and biceps: the world of female bodybuilders

Female bodybuilding used to be big – like female bodybuilders themselves – but it was a craze that wasn't built to last. Now its devotees are an endangered species.

We've been speaking barely 10 minutes when Sarah Bridges shifts her enormous upper body in the doll's-house dimensions of her chair and takes in a young man, kit bag in hand, framed in the doorway of the Dartford pub she runs with her husband, Bill.

'That's my three o'clock,' she says, waving at the newcomer, who it transpires has travelled from Dover for a physical appraisal from Sarah, one of the world's most experienced female bodybuilders. Ten minutes later in the pub kitchen the 26-year-old is ordered to strip and stand posing in his pants while Sarah points out his strengths and weaknesses. At the bar a trio of locals sip Kentish ales and pass around a bag of pork scratchings as though nothing out of the ordinary is happening.

But Sarah's dedication to bodybuilding is out of the ordinary. Fewer and fewer women in Britain are taking part in the sport; of those who do the majority are opting to adhere to more conventionally feminine classes like 'figure' and 'body fitness', seeing the bulkier frames of women like Sarah as a throwback to the heyday of bodybuilding in the 1980s, when bigger was better and Arnie was king.

 

Exercise Is NOT the Key to Weight Loss

 

In the last 20 years, the number of overweight children and adolescents has tripled. Adults have fared just as poorly. Currently more than two thirds - almost 70% - of Americans are considered overweight or obese.

But it has very little to do with how much or the types of food we put in our mouths. That is, if you listen to the candy and snack food manufacturers, beverage companies, processed food industry and the fast food restaurants. According to these groups, the reasons why we are so fat are because we are just lazy and sedentary. We don't exercise enough.

Obesity in the USA

There appears to be no end in sight for the American cycle of eating itself to death. The economy hasn’t gotten much better, and the medical community consistently points out a lack of messaging and programming to stop the alarming increase in American obesity.

New information from the U.S. Centers for Disease Control and Prevention (CDC) show that obesity is up among both sexes, among every race, and in all 50 states. Overall obesity rates were up about 4 percent in 2009 as compared to 2007 – which translates to 26.7 of the American population being obese, up from 25.6 in 2007.

 

HAPPY MEAL??

Vladimir Lenin, King Tut and the McDonald's Happy Meal: What do they all have in common? A shocking resistance to Mother Nature's cycle of decomposition and biodegradability, apparently.

That's the disturbing point brought home by the latest project of New York City-based artist and photographer Sally Davies, who bought a McDonald's Happy Meal back in April and left it out in her kitchen to see how well it would hold up over time.

The results? "The only change that I can see is that it has become hard as a rock," Davies told the U.K. Daily Mail.

 

Turn back the clock on aging muscles

 

Regular exercise can turn back the clock for aging muscle.

It may not be the fountain of youth, but researchers at York University have discovered that regular exercise can effectively turn back the clock for aging skeletal muscle.

The study, “Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle,” was recently published in the journal Aging. The results indicate that the elderly are able to rebuild muscle mass, and while they will not achieve the abs of a 20-year-old, they can reverse significant damage and loss of muscle function caused by inactivity and old age.

 

 

Aging muscles

Have you ever noticed that people have thinner arms and legs as they get older? As we age it becomes harder to keep our muscles healthy. They get smaller, which decreases strength and increases the likelihood of falls and fractures. New research is showing how this happens — and what to do about it.

A team of Nottingham researchers has already shown that when older people eat, they cannot make muscle as fast as the young. Now they’ve found that the suppression of muscle breakdown, which also happens during feeding, is blunted with age.